REARRANGEMENT STUDIES WITH C14: XII. THE REACTION OF NITROUS ACID WITH 2-α- OR 2-β-NAPHTHYLETHYLAMINE-1-C14

Metabolism of pyruvic acid-2-C14 and hydroxypyruvic acid-2-C14 in algae.

The metabolism of pyruvic acid in the light and dark by Scenedesmus has been examined with two aims: to study the relationship of its metabolism to that of the intermediates of C1402 fixation and to compare its metabolic fate with that of hydroxypyruvate. The metabolism of hydroxypyruvic acid was compared with that of C1402 fixation in order to ascertain whether it might be a photosynthetic int...

Studies on fluorinated pyrimidines. III. The metabolism of 5-fluorouracil-2-C14 and 5-fluoroorotic-2-C14 acid in vivo.

As one of the initial steps towards the determi nation of the metabolism and mechanism of action of fluorinated pyrimidines, 5-fluorouracil and 5fluoroorotic acid were labeled with radiocarbon in the 2-carbon atom. We have previously reported briefly that fluorouracil is incorporated, as such, into the combined nucleic acids of mouse liver, spleen, and Ehrlich ascites cells (9). The present rep...

Conversion of DL-lactate-2-C14 or -3-C14 or pyruvate-2-C14 to blood glucose in humans: effects of diabetes, insulin, tolbutamide, and glucose load.

The metabolism of ascorbic acid-1-C14 and oxalic acid-C14 in the rat.

It is known that oxalic acid is a product of ascorbic acid metabolism in the guinea pig (1) and rat (2), and is formed in man from unidentified precursors (3). Oxalates are also of interest because of their occasional toxicity and unexplained deposition. Ascorbic, dehydroascorbic, and 2,3diketogulonic acids are known to give rise to oxalic and threonic acids in approximately quantitative yields...

The incorporation of formate-C14, glycine-2-C14, adenine-4, 6-C14, and phosphate-P32 into nucleic acids.

nine labeled either with C'4 or N'5. Considerable controversy has developed as to which one of these tracer compounds gives an accurate measurement of the “relativeturnover-rate― of the nucleic acids. In order to determine the “absolute turnover rate― of the nucleic acids, it is necessary to know the specific activity of the immediate precursor of the nucleic acids. Since even the ident...